发明申请
- 专利标题: 1,7-Naphthyridines as Pde4 Inhibitors
- 专利标题(中): 1,7-萘乙酸作为Pde4抑制剂
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申请号: US11908188申请日: 2006-03-16
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公开(公告)号: US20080146563A1公开(公告)日: 2008-06-19
- 发明人: Colin David Eldred , John Edward Robinson
- 申请人: Colin David Eldred , John Edward Robinson
- 专利权人: Glaxo Group Limited
- 当前专利权人: Glaxo Group Limited
- 优先权: GB0505621.3 20050318
- 国际申请: PCT/EP2006/002543 WO 20060316
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; C07D221/04 ; A61K31/4375 ; A61K31/496 ; A61P37/08 ; A61P29/00 ; C07D295/00
摘要:
There are provided according to the invention novel compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof: wherein R1 is selected from the group consisting of C1-4alkyl, C4-6cycloalkyl(CH2)m—, methoxyC2-4alkyl, HOCH2CH2—, R3(O)2S(CH2)2—, R5R4NCO(CH2)n—, and heterocyclyl(CH2)m— wherein any nitrogen heteroatom of the heterocyclyl radical may be unsubstituted or substituted by methyl; R2 is hydrogen or methyl; R3 is methyl or NH2; R4-5 independently represent methyl, m is 0, 1 or 2; and n is 1 or 2; or R1 and R2 together with the nitrogen atom to which they are attached may form a heterocyclyl ring, which may be unsubstituted or substituted by one or two substituents selected from the group consisting of; methyl, ═O and (CH3)2N—.