发明申请
- 专利标题: 2-IMIDAZOLES
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申请号: US11950446申请日: 2007-12-05
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公开(公告)号: US20080146634A1公开(公告)日: 2008-06-19
- 发明人: Guido Galley , Katrin Groebke Zbinden , Roger Norcross , Henri Stalder
- 申请人: Guido Galley , Katrin Groebke Zbinden , Roger Norcross , Henri Stalder
- 优先权: EP06126005.5 20061213
- 主分类号: A61K31/4168
- IPC分类号: A61K31/4168 ; A61K31/4164 ; C07D233/64 ; C07D233/88
摘要:
The present invention relates to compounds of formula I, wherein X is —CH2— or —NH—; Y is —CH(lower alkoxy)-, —CH(lower alkyl)-, —O—, —S—, —S(O)—, —S(O)2— or —CH2—; and Ar is phenyl or naphthyl, which rings are optionally substituted by one or two substituents selected from the group consisting of halogen, lower alkoxy, lower alkyl and lower alkyl substituted by halogen; or a pharmaceutically-acceptable acid-addition salt thereof; with the proviso that, when X is —NH—, Y is —CH(lower alkyl)- or —CH2—; and the further proviso that the compound is not 2-phenethyl-1H-imidazole hydrochloride, 2-(3,4-dichloro-phenoxymethyl)-1H-imidazole hydrochloride, 2-(2-chloro-phenoxymethyl)-1H-imidazole hydrochloride, 2-(2,3-dichloro-phenoxymethyl)-1H-imidazole, benzyl-(1H-imidazol-2-yl)-amine, (4-chloro-benzyl)-(1H-imidazol-2-yl)-amine, or (2-chloro-benzyl)-(1H-imidazol-2-yl)-amine. The invention relates also to a pharmaceutically-acceptable acid-addition salt of such a compound, processes for making the compound, and a composition comprising such a compound.
公开/授权文献
- US07858653B2 2-imidazoles 公开/授权日:2010-12-28
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