A system and method to model a tracking curve of an in-vivo device capturing in-vivo data of the colon is provided. Data analysis is performed on a raw tracking curve to identify one or more milestone data points that correspond to defined locations in the colon. A modeled path may be defined between and along the selected milestone data points. Raw tracking curve data may be translated to modeled data along the modeled path. The modeled tracking curve may be displayed alongside a streaming display of captured in-vivo image frames of the colon.