A dental floss holder includes an integral interproximal pick having a plurality of outwardly extending nubs. In one embodiment, the dental floss holder includes a handle having a first portion and a second portion. A pair of arms extend from the first portion with a strand of dental floss stretched therebetween. An interproximal pick extends from the second portion. The interproximal pick includes a plurality of nubs that extend outwardly from the pick. The handle, arms and interproximal pick may be a single, integrally molded piece.