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发明申请
US20080153785A1 Pharmaceutical Compositions Containing Biophosphonate for Improving Oral Absorption 审中-公开
含有生物膦酸盐用于改善口服吸收的药物组合物

Pharmaceutical Compositions Containing Biophosphonate for Improving Oral Absorption
摘要：
Provided is a pharmaceutical composition having improved oral absorption of a bisphosphonate drug, comprising at least one active substance selected from bisphosphonate drugs having non-permeability to a lipid biomembrane due to ionization and high water-solubility in vivo and having bioavailability of less than 10%, and at least one selected from biocompatible water-soluble chitosan, as essential ingredients.
摘要（中）：

本发明提供了具有改善的双膦酸盐药物口服吸收的药物组合物，其包含至少一种活性物质，所述活性物质由于离子化而对脂质生物膜具有非渗透性，并且在体内具有高水溶性，并且具有小于10％的生物利用度 ，和选自生物相容性水溶性壳聚糖中的至少一种作为必需成分。

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