Various embodiments detect security vulnerabilities and, responsively, can modify an affected program so that even if an exploit runs, the program's integrity can be maintained. In at least some embodiments, a local automatic vulnerability detection and response (AVD/R) component executes on a user's local machine to detect and mitigate potential vulnerabilities through the use of a shield; and, a remote automatic vulnerability detection and response (AVD/R) component executes to report perceived vulnerabilities so that one or more shields can be delivered and applied locally to mitigate perceived vulnerabilities.