发明申请
- 专利标题: Triazole Compounds Suitable for Treating Disorders that Respond to Modulation of the Dopamine D3 Receptor
- 专利标题(中): 适用于治疗多巴胺D3受体调节反应的三唑化合物
-
申请号: US11792596申请日: 2005-12-01
-
公开(公告)号: US20080171751A1公开(公告)日: 2008-07-17
- 发明人: Liliane Unger , Andreas Haupt , Armin Beyerbach , Karla Drescher , Wilfried Braje , John Darbyshire , Sean C. Turner , Gisela Backfisch
- 申请人: Liliane Unger , Andreas Haupt , Armin Beyerbach , Karla Drescher , Wilfried Braje , John Darbyshire , Sean C. Turner , Gisela Backfisch
- 国际申请: PCT/EP05/12856 WO 20051201
- 主分类号: A61K31/496
- IPC分类号: A61K31/496 ; C07D403/14 ; A61P25/00
摘要:
The invention relates to compounds of the formula I: wherein n is 1 or 2, Ar is a C-bound 1,2,4-triazol radical which carries a radical R1 on the remaining carbon atom and a radical R1a on one of the nitrogen atoms; R1 is hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C4 alkoxymethyl, fluorinated C1-C6 alkyl, fluorinated C3-C6 cycloalkyl, fluorinated C1-C4 alkoxymethyl, or optionally substituted phenyl or 5- or 6-membered heteroaryl; R1a is hydrogen or C1-C4 alkyl; and R2 is C1-C6 alkyl, C3-C6 cycloalkyl, fluorinated C1-C6 alkyl or fluorinated C3-C6 cycloalkyl; and to the physiologically tolerated acid addition salts of these compounds. The invention also relates to a pharmaceutical composition that comprises at least one triazole compound of the formula I and/or at least one physiologically tolerated acid addition salt thereof, and further to a method for treating disorders that respond beneficially to dopamine D3 receptor antagonists or dopamine D3 agonists, said method comprising administering an effective amount of at least one triazole compound or physiologically tolerated acid addition salt of the formula I to a subject in need thereof.
公开/授权文献
信息查询
IPC分类: