发明申请
US20080171776A1 6-OXAZOL-4-YLMETHOLMETHOXY-ALKO-ALKOXYMETHYL SUBSTITUTED BENZOIC ACID DERIVATIVES FORMING PEROXISOME PROLIFERATOR - ACTIVATED RECEPTOR (PPAR) LIGANDS, PROCESS FOR THEIR PREPARATION AND METHODS OF USE THEREOF
有权
形成过氧化物增效剂 - 活化受体（PPAR）配体的6-氧杂-4-甲基-4-羟基乙氧基-α-烷氧基甲基取代的苯甲酸衍生物，其制备方法及其使用方法
- 专利标题： 6-OXAZOL-4-YLMETHOLMETHOXY-ALKO-ALKOXYMETHYL SUBSTITUTED BENZOIC ACID DERIVATIVES FORMING PEROXISOME PROLIFERATOR - ACTIVATED RECEPTOR (PPAR) LIGANDS, PROCESS FOR THEIR PREPARATION AND METHODS OF USE THEREOF
- 专利标题（中）： 形成过氧化物增效剂 - 活化受体（PPAR）配体的6-氧杂-4-甲基-4-羟基乙氧基-α-烷氧基甲基取代的苯甲酸衍生物，其制备方法及其使用方法
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申请号： US11949833申请日： 2007-12-04
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公开(公告)号： US20080171776A1公开(公告)日： 2008-07-17
- 发明人: Christian STAPPER , Heiner GLOMBIK , Eugen FALK , Stefanie KEIL , Hans-Ludwig SCHAEFER , Wolfgang WENDLER , Stephanie HACHTEL
- 申请人： Christian STAPPER , Heiner GLOMBIK , Eugen FALK , Stefanie KEIL , Hans-Ludwig SCHAEFER , Wolfgang WENDLER , Stephanie HACHTEL
- 申请人地址： FR Paris
- 专利权人： SANOFI-AVENTIS
- 当前专利权人： SANOFI-AVENTIS
- 当前专利权人地址： FR Paris
- 优先权： DE102005029382.4 20050624
- 主分类号： A61K31/421
- IPC分类号： A61K31/421 ; C07D263/32 ; A61P3/00 ; A61P3/10 ; A61P3/08
摘要：
The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistance and the like comprising acetic acid derivatives with cyclohexylmethoxy substituents and their salts. Known as peroxisome proliferator-activated receptor (PPAR) agonists/antagonists, the invention relates to compounds of formula I wherein R1-R6 are further defined herein.