A refrigerator with thermal-electric semiconductor comprises: a power supply, a thermal-electric semiconductor, a cooling water box, a cyclic water box, and a low temperature heat transfer unit; the cooling water box being a hollow box with cooling water therein; the water inlet tube and water outlet tube of the cooling water box being connected to the cyclic water box; a cold surface of the thermal-electric semiconductor being adhered to one side of the low temperature heat transfer unit; another side of the low temperature heat transfer unit entering into a body of a refrigerator; the low temperature heat transfer unit separating the refrigerator into a freezer and a freezing compartment; the low temperature heat transfer unit being with a temperature sensor and a temperature control circuit for controlling temperature.