发明申请
- 专利标题: MACROCYLIC OXIMYL HEPATITIS C PROTEASE INHIBITORS
- 专利标题(中): 大环氧合酶抑制剂C蛋白酶抑制剂
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申请号: US12016643申请日: 2008-01-18
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公开(公告)号: US20080181868A1公开(公告)日: 2008-07-31
- 发明人: Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
- 申请人: Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
- 主分类号: A61K31/407
- IPC分类号: A61K31/407 ; A61K38/21 ; A61P31/12
摘要:
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
公开/授权文献
- US08268776B2 Macrocylic oximyl hepatitis C protease inhibitors 公开/授权日:2012-09-18