发明申请
- 专利标题： Tetra-Cyclic Carboline Derivatives Useful in the Inhibition of Angiogenesis
- 专利标题（中）： 用于抑制血管发生的四环类衍生物
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申请号： US10592761申请日： 2005-03-15
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公开(公告)号： US20080182866A1公开(公告)日： 2008-07-31
- 发明人: Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson
- 申请人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson
- 专利权人： PTC Therapeutics , Inc. a corporation
- 当前专利权人： PTC Therapeutics , Inc. a corporation
- 国际申请： PCT/US2005/008452 WO 20050315
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; A61P43/00
摘要：
In accordance with the present invention, tetracyclic caboline derivatives that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, these compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
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