A guide wire comprises a wire body including a filamentous first wire disposed on the distal side and comprised of a Ni—Ti alloy, and a filamentous second wire disposed on the proximal side of the first wire and comprised of a material higher in rigidity than the material constituting the first wire, with the first and second wires being connected to each other. The guide wire preferably includes a flexible member which is flexible and which covers the outer periphery of a portion, on at least the distal side, of the wire body. In the guide wire, a boundary portion between the proximal portion of the first wire and the distal portion of the second wire is located inside the flexible member.