An amplifier system includes an instrumentation amplifier arrangement being designed to amplify the difference between two voltage inputs with a defined gain, and to produce a single-ended output referenced to a known reference point. A front end circuit is coupled to the instrumentation amplifier. The front end circuit is configured to include a current clamp to actively limit the current in a gain resistor of the instrumentation amplifier to prevent input currents flowing when the instrumentation amplifier is over-driven.