In this patent, we propose an efficient CCI cancellation algorithm capable of working in cellular OFDM systems in high interference environments especially for users at the cell edges. We propose modified BSs' transmitters (Txs) and MS receiver (Rx) structures. Adjacent BSs use different transmitting interleaving patterns. This leads to orthogonality in the frequency domain. Furthermore, the energy of every symbol is spread over two different subcarriers to get frequency diversity. At the MS Rx, the maximum likelihood estimator MLE CCI canceller is applied to cancel signals of interfering BSs using the same frequency band. A drawback of the MLE CCI canceller is that its performances is degraded when the received power of desired and interferer signals is nearly the same. To solve this problem, the MLE CCI canceller is assisted by a closed-loop power control (CPC) scheme. The newly proposed CPC scheme is capable of detecting and combating against the situation where the equal power is received. The present invention is easily extended to cellular networks where more than one interferer signals can be considered in the MLE CCI canceller and variable number of interleaving patterns can be applied. As a result of all the above, the invention in hands can efficiently reduces the effect the CCI in cellular OFDM networks.