发明申请
US20080193518A1 Process for the precipitation and isolation of 6,6-Dimethyl-3-Aza Bicyclo [3.1.0] Hexane-Amide compounds by controlled precipitation and pharmaceutical formulations containing same
审中-公开
6,6-二甲基-3-氮杂双环[3.1.0]己烷 - 酰胺化合物的沉淀和分离方法，通过控制沉淀和含有相同的药物制剂
![Process for the precipitation and isolation of 6,6-Dimethyl-3-Aza Bicyclo [3.1.0] Hexane-Amide compounds by controlled precipitation and pharmaceutical formulations containing same](/docs/US/2008-08-14/US20080193518A1/abs.jpg.600x600.jpg)
- 专利标题： Process for the precipitation and isolation of 6,6-Dimethyl-3-Aza Bicyclo [3.1.0] Hexane-Amide compounds by controlled precipitation and pharmaceutical formulations containing same
- 专利标题（中）： 6,6-二甲基-3-氮杂双环[3.1.0]己烷 - 酰胺化合物的沉淀和分离方法，通过控制沉淀和含有相同的药物制剂
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申请号： US11789915申请日： 2007-04-26
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公开(公告)号： US20080193518A1公开(公告)日： 2008-08-14
- 发明人: Dimitrios Zarkadas , Vincenzo Liotta , Christopher Stanley Pridgen , Wing-Kee Philip Cho , Zhihui Qiu
- 申请人： Dimitrios Zarkadas , Vincenzo Liotta , Christopher Stanley Pridgen , Wing-Kee Philip Cho , Zhihui Qiu
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 主分类号： A61K9/48
- IPC分类号： A61K9/48 ; C07D209/00 ; A61K9/14 ; A61P43/00 ; A61K31/40
![Process for the precipitation and isolation of 6,6-Dimethyl-3-Aza Bicyclo [3.1.0] Hexane-Amide compounds by controlled precipitation and pharmaceutical formulations containing same](/abs-image/US/2008/08/14/US20080193518A1/abs.jpg.150x150.jpg)
摘要：
The present invention provides a method of continuous precipitation and isolation of an amorphous solid particulate form of 3-[2-(3-tert-Butyl-ureido)-3,3-dimethyl-butyryl]-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid (2-carbamoyl-1-cyclobutylmethyl-2-oxo-ethyl)-amide having controlled physical properties. The present invention provides also pharmaceutical formulations comprising the precipitated compound.
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