A novel process neutralizes airborne pathogens by using microwave powered ultra violet light combined with catalyzed filters and impingement media made of a layer of Filtrite filter media or comparable brand filter media covering an aerogel blanket. The geometric design maximizes the efficiency of the UV light, and impingement of pathogens on the Filtrite filter media/aerogel blanket catalyzed surfaces. The system can be utilized for preventing sick building syndrome (SBS), to prevent the spread of airborne diseases in hospitals, biohazard research laboratories, food and pharmaceutical processing facilities, and biological weapons storage facilities. It can also be used in HVAC systems to minimize the contamination caused by a biological terrorist attack.