发明申请
US20080200663A1 NOVEL LENTIVIRAL VECTORS FOR SITE-SPECIFIC GENE INSERTION
有权
用于特定基因插入的新颖的LENIVEIRAL VECTORS
- 专利标题： NOVEL LENTIVIRAL VECTORS FOR SITE-SPECIFIC GENE INSERTION
- 专利标题（中）： 用于特定基因插入的新颖的LENIVEIRAL VECTORS
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申请号： US12107015申请日： 2008-04-21
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公开(公告)号： US20080200663A1公开(公告)日： 2008-08-21
- 发明人: Jiing-Kuan Yee , Gilles H. Michel
- 申请人： Jiing-Kuan Yee , Gilles H. Michel
- 专利权人： CITY OF HOPE
- 当前专利权人： CITY OF HOPE
- 主分类号： C07H21/04
- IPC分类号： C07H21/04
摘要：
Murine leukemia virus (MLV) and lentivirus vectors have been used previously to deliver genes to hematopoietic stem cells (HSCs) in human gene therapy trials. However, these vectors integrate randomly into the host genome, leading to disruption or inactivation of vital host genes. The present invention discloses a novel lentiviral vector system that overcomes this problem by integrating into a host genome in a site-specific manner.
公开/授权文献
- US07531647B2 Lentiviral vectors for site-specific gene insertion 公开/授权日：2009-05-12
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