发明申请
US20080207617A1 Quinoline Derivatives and Quinazoline Derivatives Inhibiting Autophosphrylation of Flt3 and Medicinal Compositions Containing the Same
审中-公开
喹啉衍生物和喹唑啉衍生物抑制Flt3和含有它的药用组合物的自磷酸化
- 专利标题： Quinoline Derivatives and Quinazoline Derivatives Inhibiting Autophosphrylation of Flt3 and Medicinal Compositions Containing the Same
- 专利标题（中）： 喹啉衍生物和喹唑啉衍生物抑制Flt3和含有它的药用组合物的自磷酸化
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申请号： US10533081申请日： 2003-10-29
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公开(公告)号： US20080207617A1公开(公告)日： 2008-08-28
- 发明人: Atsushi Miwa , Tetsuya Yoshino , Mineo Kurokawa , Hisamaru Hirai , Naoko Hirai
- 申请人： Atsushi Miwa , Tetsuya Yoshino , Mineo Kurokawa , Hisamaru Hirai , Naoko Hirai
- 申请人地址： JP TOKYO -TO- JAPAN
- 专利权人： KIRIN BEER KABUSHIKI KAISHA
- 当前专利权人： KIRIN BEER KABUSHIKI KAISHA
- 当前专利权人地址： JP TOKYO -TO- JAPAN
- 优先权： JP2002-314670 20021029
- 国际申请： PCT/JP03/13848 WO 20031029
- 主分类号： A61K31/4709
- IPC分类号： A61K31/4709 ; C07D215/233 ; C07D401/12 ; C07D413/12 ; A61P35/02 ; A61P35/00 ; A61K31/496 ; A61K31/5377 ; A61K31/47
摘要：
An objective of the present invention is to provide compounds and pharmaceuticals useful for the treatment of disease where the inhibition of autophosphorylation of FMS-like tyrosine kinase 3(Flt3) is therapeutically effective. The present invention relates to a pharmaceutical composition for use in the treatment or prevention of diseases where the inhibition of autophosphorylation of Flt3 therapeutically or prophylactically effective, which comprises a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; R1, R2, and R3 represent H, OH, or optionally substituted alkoxy; R4 represents H; R5, R6, R7, and R8 represent H, Hal, alkyl or the like; and R9 represents, e.g., alkyl substituted by t-butyl or the like.
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