发明申请
- 专利标题: 1-Amino Linked Compounds
- 专利标题(中): 1-氨基连接的化合物
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申请号: US11996128申请日: 2006-07-14
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公开(公告)号: US20080207735A1公开(公告)日: 2008-08-28
- 发明人: Larry Chris Blaszczak , Shon Roland Pulley , Michael Alan Robertson , Scott Martin Sheehan , Qing Shi , Michael Robert Wiley
- 申请人: Larry Chris Blaszczak , Shon Roland Pulley , Michael Alan Robertson , Scott Martin Sheehan , Qing Shi , Michael Robert Wiley
- 国际申请: PCT/US06/27671 WO 20060714
- 主分类号: A61K31/40
- IPC分类号: A61K31/40 ; C07C215/28 ; A61K31/138 ; A61P3/10 ; A61P3/04 ; C07D207/09
摘要:
The present invention is directed to compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein A is (II); X is selected from CH, CF and N, R8 is selected from H, C1-C6 alkyl, aryl, heteroaryl, C1-C6 alkylaryl, C1-C6 alkylheteroaryl, C2-C6 alkyl-O—C1-C6 alkyl, C1-C6 haloalkyl, hydroxy C2-C6 alkyl, —C(O)R9 and —SO2R9, or R7 and R8 combine to form (III), (IV); W is selected from CR1O and CR15, R1O is selected from H, halo, —C(O)NR13R14, C1-C6 alkyl, aryl, heteroaryl, C1-C6 alkylaryl, C1-C6 alkylheteroaryl, C1-C6 alkyl-O—C1-C6 alkyl and hydroxy C1-C6 alkyl; Het is a N-linked 5-membered heteroaryl ring optionally substituted with 1-3 substituents selected from methoxy, Cl, F, CH3, CF3, aryl, heteroaryl, C1-C4 alkylaryl or C1-C4 alkylheteroaryl, for use as inhibitors of the DPP-IV enzyme in the treatment or prevention of conditions including Type II diabetes.
公开/授权文献
- US08106090B2 1-amino linked compounds 公开/授权日:2012-01-31
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