发明申请
- 专利标题: Vectors for tissue-specific replication
- 专利标题(中): 用于组织特异性复制的载体
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申请号: US11977902申请日: 2007-10-25
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公开(公告)号: US20080213884A1公开(公告)日: 2008-09-04
- 发明人: Paul L. Hallenbeck , Yung-Nien Chang , Yawen L. Chiang
- 申请人: Paul L. Hallenbeck , Yung-Nien Chang , Yawen L. Chiang
- 申请人地址: US CA South San Francisco
- 专利权人: Cell Genesys, Inc.
- 当前专利权人: Cell Genesys, Inc.
- 当前专利权人地址: US CA South San Francisco
- 主分类号: C12N5/06
- IPC分类号: C12N5/06
摘要:
The invention generally relates to targeted gene therapy using recombinant vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional vectors and methods for using them. Such vectors are able to selectively replicate in a target tissue to provide a therapeutic benefit from the presence of the vector per se or from heterologous gene products expressed from the vector and distributed throughout the tissue. In such vectors, a gene essential for replication is placed under the control of a heterologous tissue-specific transcriptional regulatory sequence. Thus, replication is conditioned on the presence of a factor(s) that induces transcription or the absence of a factor(s) that inhibits transcription of the gene by means of the transcriptional regulatory sequence with this vector, therefore, a target tissue can be selectively treated.