发明申请
- 专利标题： Sensitization of Drug-Resistant Lung Caners to Protein Kinase Inhibitors
- 专利标题（中）： 耐药肺癌致敏蛋白激酶抑制剂
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申请号： US11997915申请日： 2006-08-07
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公开(公告)号： US20080214521A1公开(公告)日： 2008-09-04
- 发明人: Martin Schuler
- 申请人： Martin Schuler
- 国际申请： PCT/EP2006/065122 WO 20060807
- 主分类号： A61K31/553
- IPC分类号： A61K31/553 ; A61P35/00
摘要：
The present invention relates to a method of treating non-small cell lung cancer with FLT-3 kinase inhibitor such as PKC412. The invention also relates to a pharmaceutical combination of a FLT-3 kinase inhibitor and an activator of permeabilization of the mitochondrial outer membrane, such as an activator of BAK. It also relates to the use of a pharmaceutical combination of an activator of permeabilization of the mitochondrial outer membrane and a FLT-3 kinase inhibitor for the treatment of non-small cell lung cancer and the use of such a pharmaceutical composition for the manufacture of a medicament for the treatment of same.
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