Crystal oscillator control and calibration is disclosed. Temperature and frequency control circuits included on a printed circuit board (PCB) comprising a crystal oscillator are used to determine, for each of a plurality of set points in a range of sensed internal temperatures sensed by an internal temperature sensing circuit or device located adjacent to the oscillator in a thermally insulated region of the PCB, a corresponding compensation required to be applied to maintain a desired oscillator output frequency. The PCB is configured to use at least the determined compensation values and a sensed internal temperature to determine during operation of the PCB a compensation, if any, to be applied to maintain the desired oscillator output frequency.