发明申请
US20080221152A1 4-(HETEROARYL-METHYL AND SUBSTITUTED HETEROARYL-METHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS
审中-公开
作为ALPHA2 ADRENERGIC AGONISTS的4-（异丁基 - 甲基和取代的杂芳基 - 甲基） - 咪唑-2-酮
- 专利标题： 4-(HETEROARYL-METHYL AND SUBSTITUTED HETEROARYL-METHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS
- 专利标题（中）： 作为ALPHA2 ADRENERGIC AGONISTS的4-（异丁基 - 甲基和取代的杂芳基 - 甲基） - 咪唑-2-酮
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申请号： US12123578申请日： 2008-05-20
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公开(公告)号： US20080221152A1公开(公告)日： 2008-09-11
- 发明人: Todd M. Heidelbaugh , Ken Chow , Phong X. Nguyen , Daniel W. Gil , John E. Donello , Michael E. Garst , Larry A. Wheeler
- 申请人： Todd M. Heidelbaugh , Ken Chow , Phong X. Nguyen , Daniel W. Gil , John E. Donello , Michael E. Garst , Larry A. Wheeler
- 申请人地址： US CA Irvine
- 专利权人： ALLERGAN, INC.
- 当前专利权人： ALLERGAN, INC.
- 当前专利权人地址： US CA Irvine
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; C07D403/06 ; A61K31/4178 ; A61K31/4439 ; A61P25/00 ; A61P25/30 ; A61K31/4709 ; C07D401/04 ; C07D471/04
摘要：
Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardiovascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.
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