发明申请
US20080221362A1 Optically-active bis(alkynylphosphino) ethane-borane derivative and process for producing the same
失效
光学活性双(炔基膦基)乙烷 - 硼烷衍生物及其制备方法
- 专利标题: Optically-active bis(alkynylphosphino) ethane-borane derivative and process for producing the same
- 专利标题(中): 光学活性双(炔基膦基)乙烷 - 硼烷衍生物及其制备方法
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申请号: US12073415申请日: 2008-03-05
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公开(公告)号: US20080221362A1公开(公告)日: 2008-09-11
- 发明人: Tsuneo Imamoto , Kazuhiro Yoshida , Youichi Saitoh , Aya Koide
- 申请人: Tsuneo Imamoto , Kazuhiro Yoshida , Youichi Saitoh , Aya Koide
- 申请人地址: JP Tokyo JP Chiba-shi
- 专利权人: Nippon Chemical Industrial Co., Ltd.,National University Corporation Chiba University
- 当前专利权人: Nippon Chemical Industrial Co., Ltd.,National University Corporation Chiba University
- 当前专利权人地址: JP Tokyo JP Chiba-shi
- 优先权: JP2007-060784 20070309
- 主分类号: C07F9/54
- IPC分类号: C07F9/54
摘要:
An optically-active bis(alkynylphosphino)ethane-borane derivative represented by formula (1): wherein R1 and R2, which may be the same or different, each represent an alkyl group, a phenyl group, an alkylsilyl group or a hydrogen atom; R3 represents a branched alkyl group, an alicyclic hydrocarbon group or an aromatic hydrocarbon group; and the asterisk * indicates an optically-active site. The derivative (1) is prepared by bromination of, e.g., an (S)-t-butylmethylphosphine-borane, reaction with an alkynyl lithium, deprotonation, followed by oxidative coupling. Deprotection of the derivative (1) by deboranation gives an optically-active bis(alkynylphosphino)ethane derivative useful as a ligand providing an asymmetric catalyst for catalytic asymmetric synthesis. The asymmetric catalyst having the ligand exhibits high selectivity and catalyst activity.