A portable electronic device with a global setting user interface on a touch screen display is disclosed. The user interface has a plurality of application icons. In response to a first gesture, the GUI changes the appearances of the application icons whose corresponding applications have user-adjustable settings. In response to a second gesture on a selected application icon whose appearance is changed, the GUI displays user-adjustable settings of an application that corresponds to the selected application icon. In response to one or more additional gestures, the GUI changes one or more user-adjustable settings of the application that corresponds to the selected application icon.