Multi-core solid profile filter media blocks include multiple sub-blocks, which may be formed by providing a block with multiple interior cavities extending deep into the block, to allow water to flow deep inside the filter block to access the media of the sub-block (in the case wherein the cavities are at the inlet to the block) or that allows water to be collected from each filtration sub-block (in the case wherein the cavities are at the outlet from the block). One or more indentations/spaces/gaps in the exterior surface of the block also may be provided to separate and extend between portions of the sub-blocks, so that substantially all of the filter media of a sub-block is accessible to fluid for filtration. This way, a filter block may include a large amount of media in a small cartridge or package volume, and the filter block may exhibit good flow distribution and low pressure drop. Sub-blocks of the filter block may be integrally formed together into the filter block, or may be directly connected, for example, preferably without any housing or internals clamping or fastening the sub-blocks together.