发明申请
- 专利标题： PRODRUGS OF PHOSPHONATE NUCLEOTIDE ANALOGUES
- 专利标题（中）： 磷酸核苷类似物的研究进展
-
申请号： US12110829申请日： 2008-04-28
-
公开(公告)号： US20080227754A1公开(公告)日： 2008-09-18
- 发明人: Mark W. Becker , Harlan H. Chapman , Tomas Cihlar , Eugene J. Eisenberg , Gong-Xin He , Michael R. Kernan , William A. Lee , Ernest J. Prisbe , John C. Rohloff , Mark L. Sparacino
- 申请人： Mark W. Becker , Harlan H. Chapman , Tomas Cihlar , Eugene J. Eisenberg , Gong-Xin He , Michael R. Kernan , William A. Lee , Ernest J. Prisbe , John C. Rohloff , Mark L. Sparacino
- 主分类号： A61K31/675
- IPC分类号： A61K31/675 ; A61P31/12
摘要：
A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
公开/授权文献
- US07803788B2 Prodrugs of phosphonate nucoleotide analogues 公开/授权日：2010-09-28
信息查询
