A long term bi-directional axon-electronic communication system that provides signaling capability at the level of individual nerve fascicles, bundles of axon and even axons is disclosed. The bi-directional communication system is a modular approach for achieving a chronic enduring interface to peripheral or central nerve atoms for the purpose of restoring function to disabled persons or animals with sensory and/or motor impairments. One embodiment of the communication system includes a multi-channeled nerve-muscle graft chamber for making the nerve-muscle connection. Another embodiment includes a regeneration based microtube nerve interface for bi-directional communication. The interface communication system permits amputees to obtain simultaneous control of multi-degree of freedom powered prostheses by means of naturally produced neural activity from the stamps of the amputated nerves in their residual limbs.