发明申请
US20080233051A1 Nanoparticles for two-photon activated photodynamic therapy and imaging
审中-公开
纳米粒子用于双光子激活光动力治疗和成像
- 专利标题: Nanoparticles for two-photon activated photodynamic therapy and imaging
- 专利标题(中): 纳米粒子用于双光子激活光动力治疗和成像
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申请号: US11983845申请日: 2007-11-13
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公开(公告)号: US20080233051A1公开(公告)日: 2008-09-25
- 发明人: Paras N. Prasad , Sehoon Kim , Tymish Y. Ohulchanskyy , Ravindra K. Pandey
- 申请人: Paras N. Prasad , Sehoon Kim , Tymish Y. Ohulchanskyy , Ravindra K. Pandey
- 主分类号: A61K9/14
- IPC分类号: A61K9/14 ; A61K31/695 ; A61K49/00
摘要:
The present invention provides organically modified silica (ORMOSIL) nanoparticles into which have been incorporated two-photon absorption dye molecules. The two photon absorption dye displays a unique aggregation induced fluorescence enhancement behavior. As a result ORMOSIL nanoparticles with high amounts of the dye can be prepared. These particles can be used for imaging. In one embodiment, the nanoparticles can additionally have incorporated therein a photosensitizer. The photosensitizer can be activated by intraparticle fluorescence resonance energy transfer (FRET) from the dye aggregates resulting in enhanced fluorescence and singlet oxygen generation from photosensitizer under two-photon excitation conditions. Such nanoparticles can be used for photodynamic therapy applications.