发明申请
- 专利标题： Vaccine Composition
- 专利标题（中）： 疫苗组成
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申请号： US11467396申请日： 2006-08-25
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公开(公告)号： US20080233154A1公开(公告)日： 2008-09-25
- 发明人: Francois-Xavier Jacques Berthet , Wilfried Dalemans , Philippe Denoel , Guy Dequesne , Christiane Feron , Yves Lobet , Jan Poolman , Georges Thiry , Joelle Thonnard , Pierre Voet
- 申请人： Francois-Xavier Jacques Berthet , Wilfried Dalemans , Philippe Denoel , Guy Dequesne , Christiane Feron , Yves Lobet , Jan Poolman , Georges Thiry , Joelle Thonnard , Pierre Voet
- 专利权人： SmithKline Beecham Biologicals s.a.
- 当前专利权人： SmithKline Beecham Biologicals s.a.
- 优先权： GB9918319.6 19990803
- 主分类号： A61K39/095
- IPC分类号： A61K39/095 ; A61P31/04
摘要：
The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
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