A thermal treatment device for forming a micropore in a barrier has a micro-heater component with at least one micro-heater with a thermal member having a base end and a tip end. The device also has an ablation material in the at least one micro-heater and a power supply component for activating the micro-heater component. The ablation material expands in response to the activation in order to mechanically puncture the barrier to a first depth without thermally inducing ablation of the barrier and the micro-heater component enlarges the first depth of the micropore to a second depth and/or produces an improvement in at least one physiological property of the micropore.