Techniques and tools are described for adaptive deadzone (“DZ”) resizing during quantization. For example, in some embodiments, for quantization of an AC frequency coefficient of a block, a video encoder adjusts DZ size of a selected quantizer depending on the texture of the block. In other embodiments, a video encoder adjusts DZ size depending on the frequency of a coefficient being quantized. In still other embodiments, for quantization of an AC frequency coefficient of a block, a video encoder adjusts DZ size depending on the texture of the block and the frequency of the coefficient being quantized.