发明申请
US20080241134A1 USES OF HUMAN MONOCLONAL ANTIBODIES AGAINST OXIDIZED LDL RECEPTOR
失效
人类单克隆抗体对氧化LDL受体的使用
- 专利标题： USES OF HUMAN MONOCLONAL ANTIBODIES AGAINST OXIDIZED LDL RECEPTOR
- 专利标题（中）： 人类单克隆抗体对氧化LDL受体的使用
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申请号： US11740857申请日： 2007-04-26
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公开(公告)号： US20080241134A1公开(公告)日： 2008-10-02
- 发明人: Yuko Kobayashi , Hiroyuki Tsuji , Masafumi Kamada , Tatsuya Sawamura
- 申请人： Yuko Kobayashi , Hiroyuki Tsuji , Masafumi Kamada , Tatsuya Sawamura
- 申请人地址： US CA Fremont
- 专利权人： ABGENIX, INC.
- 当前专利权人： ABGENIX, INC.
- 当前专利权人地址： US CA Fremont
- 优先权： JP2000-057745 20000302; JP2000-333116 20001031; JPPCT/JP01/01636 20010302
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/28 ; C12N5/06 ; A61P7/00
摘要：
Various human monoclonal antibodies that bind to human LOX-1 and inhibit the binding of in-vivo LOX-1 ligands to LOX-1, and the LOX-1-mediated incorporation of the ligands into cells, were obtained by immunizing human antibody-producing transgenic mice (created by genetic engineering) with soluble human oxidized LDL receptor (LOX-1). Furthermore, the human monoclonal antibodies were found to be effective in preventing and treating a variety of diseases
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