发明申请
US20080242714A1 Novel 5-cyano-prostacyclin derivatives as agents for the treatment of influenza a viral infection
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新型5-氰基 - 前列环素衍生物作为治疗流感病毒感染的药剂
- 专利标题： Novel 5-cyano-prostacyclin derivatives as agents for the treatment of influenza a viral infection
- 专利标题（中）： 新型5-氰基 - 前列环素衍生物作为治疗流感病毒感染的药剂
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申请号： US12079602申请日： 2008-03-27
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公开(公告)号： US20080242714A1公开(公告)日： 2008-10-02
- 发明人: William Guilford , Werner Skuballa , Daryl H. Faulds , Monica Kochanny , Wheeseong Lee , Bernd Raduchel
- 申请人： William Guilford , Werner Skuballa , Daryl H. Faulds , Monica Kochanny , Wheeseong Lee , Bernd Raduchel
- 申请人地址： DE Berlin
- 专利权人： Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人： Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人地址： DE Berlin
- 主分类号： A61K31/41
- IPC分类号： A61K31/41 ; C07D307/77 ; A61K31/365 ; A61P31/16 ; C07D405/02
摘要：
This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1-R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating respiratory diseases associated with influenza A viruses, such as for example H5N1 and its mutations. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.