发明申请
- 专利标题： COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR
- 专利标题（中）： 用于生产立体纯静止物及其合成中间体的组合物和方法
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申请号： US11865696申请日： 2007-10-01
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公开(公告)号： US20080248539A1公开(公告)日： 2008-10-09
- 发明人: Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
- 申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
- 申请人地址： US CA Redwood City
- 专利权人： Codexis, Inc.
- 当前专利权人： Codexis, Inc.
- 当前专利权人地址： US CA Redwood City
- 主分类号： C12P7/62
- IPC分类号： C12P7/62 ; C12N9/02 ; C07H21/04 ; C07D207/34 ; C07C69/675 ; C12N1/21
摘要：
The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
公开/授权文献
- US07879585B2 Ketoreductase enzymes and uses thereof 公开/授权日：2011-02-01