发明申请
US20080248575A1 Drug and Gene Delivery by Polymer Nanonozzle and Nanotip Cell Patch
审中-公开
药物和基因递送由聚合物Nanonozzle和Nanotip细胞贴片
- 专利标题: Drug and Gene Delivery by Polymer Nanonozzle and Nanotip Cell Patch
- 专利标题(中): 药物和基因递送由聚合物Nanonozzle和Nanotip细胞贴片
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申请号: US12090958申请日: 2006-10-20
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公开(公告)号: US20080248575A1公开(公告)日: 2008-10-09
- 发明人: L. James Lee , Shengnian Wang , Yubing Xie , Changchun Zeng , Chee Guan Koh , Zhengzheng Fei
- 申请人: L. James Lee , Shengnian Wang , Yubing Xie , Changchun Zeng , Chee Guan Koh , Zhengzheng Fei
- 申请人地址: US OH Columbus
- 专利权人: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
- 当前专利权人: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
- 当前专利权人地址: US OH Columbus
- 国际申请: PCT/US06/60105 WO 20061020
- 主分类号: C12N15/87
- IPC分类号: C12N15/87 ; B29C67/24 ; C12N5/06
摘要:
Delivery of drugs or genes to individual cells is achieved on a nanoscale using electroporation techniques. In one method, a flow-through bioreactor having an inlet and an outlet connected by a flow chamber and a nanoporous membrane positioned in the flow chamber is used. Cells to be electroporated are flowed from the inlet to the outlet, a quantum of molecules of the at least one drug or gene in a fluid medium in the flow chamber. An electrical field applied in the flow chamber provides momentum to the molecules in the nanopores, resulting in delivery of the molecules into the plurality of cells.
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