The composition of the present invention comprising Cucurbita moschata, Carthamus tinctorius, Plantago asiatica and Lonicera japonica has a follicle-stimulating hormone reduction action. Based on this action, the composition is usable as a preventive, remedy, health food or functional food for diseases, for example, climacteric disturbance, primary hypogonadism (including ovarian hypofunction and testicular deficiency), Turner's syndrome, Klinefelter' s syndrome, gonadotropin-producing tumor, testitis, and primary ovarian amenorrhea and/or hormone-producing tumor.