发明申请
- 专利标题： NOVEL THIOPHENE SULFOXIMINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS
- 专利标题（中）： 新型噻吩磺酰胺，其组合物和治疗补体介导的疾病和病症的方法
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申请号： US12061873申请日： 2008-04-03
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公开(公告)号： US20080255108A1公开(公告)日： 2008-10-16
- 发明人: Nalin L. Subasinghe , Shelley Ballentine , Jeremy M. Travins , Ehab M. Khalil , Farah Ali , Kristi A. Leonard , Joan M. Gushue , Michael Peter Winters , Heather Hufnagel , Maxwell David Cummings
- 申请人： Nalin L. Subasinghe , Shelley Ballentine , Jeremy M. Travins , Ehab M. Khalil , Farah Ali , Kristi A. Leonard , Joan M. Gushue , Michael Peter Winters , Heather Hufnagel , Maxwell David Cummings
- 主分类号： A61K31/538
- IPC分类号： A61K31/538 ; C07D333/02 ; A61K31/381 ; C07D263/30 ; A61K31/421 ; C07D213/02 ; A61P11/00 ; A61P19/00 ; A61P25/00 ; A61P37/00 ; A61P9/00 ; A61P3/00 ; A61P31/00 ; A61K31/44 ; C07D277/20 ; A61K31/426 ; C07D265/36
摘要：
Disclosed are compounds for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade. Said compounds are of Formula I or a solvate, hydrate, pharmaceutically acceptable salt, or prodrug thereof; wherein Ra, Rb, and Rc are defined in the specification, as are A Z, Q, R1 and R2.