发明申请
US20080255767A1 Method and Device For Detection of Splice Form and Alternative Splice Forms in Dna or Rna Sequences
审中-公开
用于检测Dna或Rna序列中的接头形式和替代接头形式的方法和装置
- 专利标题： Method and Device For Detection of Splice Form and Alternative Splice Forms in Dna or Rna Sequences
- 专利标题（中）： 用于检测Dna或Rna序列中的接头形式和替代接头形式的方法和装置
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申请号： US11597218申请日： 2005-05-25
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公开(公告)号： US20080255767A1公开(公告)日： 2008-10-16
- 发明人: Gunnar Ratsch , Soren Sonnenburg , Klaus-Robert Muller , Bernhard Scholkopf
- 申请人： Gunnar Ratsch , Soren Sonnenburg , Klaus-Robert Muller , Bernhard Scholkopf
- 申请人地址： DE Munchen DE Munchen
- 专利权人： FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN,MAX-PLANCK GESELLSCHAFT ZUR FORDERUNG DER, WISSENSCHAFTEN .E.V., BERLIN
- 当前专利权人： FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN,MAX-PLANCK GESELLSCHAFT ZUR FORDERUNG DER, WISSENSCHAFTEN .E.V., BERLIN
- 当前专利权人地址： DE Munchen DE Munchen
- 优先权： EP04012454.7 20040526; EP05090129.7 20050506
- 国际申请： PCT/EP2005/005783 WO 20050525
- 主分类号： G01N33/48
- IPC分类号： G01N33/48 ; G06F19/00
摘要：
The invention relates to a method and a device for detection of splice sites in DNA or RNA sequences comprising three steps: a) examining a training set of sequences comprising DNA or RNA sequences with known splice sites by an automated, discriminative training device for detecting splicing patterns, especially in a predetermined window around the known splice sites; b) scanning a sequence comprising DNA or RNA sequences containing unknown splice sites for the occurrence of the splicing patterns detected in step a); and c) calculation of a cumulative splice score in dependence of a maximization of the margin between the true splice forms and all wrong splice forms in the sequence. The invention also relates to a method and a device for detection of splice forms and alternative splice forms in DNA or RNA sequences.
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