发明申请
- 专利标题: Medicinal Compositions and Method for the Preparation Thereof
- 专利标题(中): 药用组合物及其制备方法
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申请号: US10596836申请日: 2004-12-10
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公开(公告)号: US20080267885A1公开(公告)日: 2008-10-30
- 发明人: John T. Capecchi , James S. Stefely , Peter M. Seiler
- 申请人: John T. Capecchi , James S. Stefely , Peter M. Seiler
- 国际申请: PCT/US04/41194 WO 20041210
- 主分类号: A61K47/48
- IPC分类号: A61K47/48 ; A61K9/12
摘要:
Methods for the manufacture of medicinal compositions are described. A method for the manufacture of a medicinal composition according to the invention comprises: (a) Providing a biocompatible polymer of the general formula —[O—R1—C(O)]n— wherein: “R1” is a linear, branched, or cyclic organic group, “n” is at least three, (b) Acylating the biocompatible polymer to provide an acylated biocompatible polymer and a mixed anhydride; (c) Reacting the mixed anhydride with a nucleophile to provide an acylated biocompatible polymer with a terminal carboxylic acid derivative capable of being chemically converted to an acid in the absence of water, (d) Converting the terminal carboxylic acid derivative to an acylated biocompatible polymer with a terminal carboxylic acid; and (e) Combining the acylated biocompatible polymer with a drug to provide the medicinal composition.