发明申请
- 专利标题: CYCLIC P3 TRIPEPTIDE HEPATITIS C SERINE PROTEASE INHIBITORS
- 专利标题(中): 循环P3三磷酸腺嘌呤C丝氨酸蛋白酶抑制剂
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申请号: US11740440申请日: 2007-04-26
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公开(公告)号: US20080267916A1公开(公告)日: 2008-10-30
- 发明人: Yonghua Gai , Deqiang Niu , Yat Sun Or , Zhe Wang
- 申请人: Yonghua Gai , Deqiang Niu , Yat Sun Or , Zhe Wang
- 主分类号: C07K5/08
- IPC分类号: C07K5/08 ; A61K38/06 ; A61P31/12 ; A61K38/21
摘要:
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
公开/授权文献
- US08377872B2 Cyclic P3 tripeptide hepatitis C serine protease inhibitors 公开/授权日:2013-02-19