发明申请
US20080268041A1 COMBINATION OF PROGESTERONE-RECEPTOR ANTAGONIST TOGETHER WITH NONE-STEROIDAL ANTIESTROGEN FOR USE IN BRCA MEDIATED DISEASES
审中-公开
孕激素受体拮抗剂与无症状性静脉注射用于BRCA介导的疾病的组合
- 专利标题： COMBINATION OF PROGESTERONE-RECEPTOR ANTAGONIST TOGETHER WITH NONE-STEROIDAL ANTIESTROGEN FOR USE IN BRCA MEDIATED DISEASES
- 专利标题（中）： 孕激素受体拮抗剂与无症状性静脉注射用于BRCA介导的疾病的组合
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申请号： US12105357申请日： 2008-04-18
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公开(公告)号： US20080268041A1公开(公告)日： 2008-10-30
- 发明人: Jens Hoffmann , Daniel Korr
- 申请人： Jens Hoffmann , Daniel Korr
- 优先权： EP07090082.4 20070423
- 主分类号： A61K9/48
- IPC分类号： A61K9/48 ; A61K31/575 ; A61P35/00
摘要：
The present invention relates to the combination of the progesterone-receptor antagonist 11β-(4-acetylphenyl)-17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-estra-4,9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof, together with at least one none-steroidal antiestrogen and to the use of said combination for the prophylaxis and treatment of BRCA1- or BRCA2-mediated diseases. None-steroidal antiestrogens which can be combined together with the progesterone-receptor antagonist 11β-(4-acetylphenyl)-17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-estra-4,9-dien-3-one are for example is tamoxifen, raloxifene, droloxifen, toremifen, lasofoxifen, arzoxifen, GW5638, EM-800, idoxifen and basedoxifene.
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