发明申请
- 专利标题： Macrocyclic Tertiary Amine Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease
- 专利标题（中）： 用于治疗阿尔茨海默病的大环叔胺β-分泌酶抑制剂
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申请号： US11667913申请日： 2005-11-14
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公开(公告)号： US20080269302A1公开(公告)日： 2008-10-30
- 发明人: Philippe G. Nantermet , Hemaka A. Rajapakse , Harold G. Selnick , Stacey Lindsley , Keith P. Moore , Shawn J. Stachel
- 申请人： Philippe G. Nantermet , Hemaka A. Rajapakse , Harold G. Selnick , Stacey Lindsley , Keith P. Moore , Shawn J. Stachel
- 申请人地址： US NJ Rahway
- 专利权人： MERCK & CO., INC.
- 当前专利权人： MERCK & CO., INC.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US05/40984 WO 20051114
- 主分类号： A61K31/365
- IPC分类号： A61K31/365 ; C07D267/00 ; C07D313/00 ; A61K31/395 ; A61P25/28 ; C07D498/00 ; C07D321/00
摘要：
The present invention is directed to macrocyclic tertiary amine compounds represented by general formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.