发明申请
- 专利标题： Modified Antibody Fragments
- 专利标题（中）： 修饰抗体片段
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申请号： US11995740申请日： 2006-07-17
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公开(公告)号： US20080269466A1公开(公告)日： 2008-10-30
- 发明人: David Paul Humphreys
- 申请人： David Paul Humphreys
- 申请人地址： BE Brussels
- 专利权人： UCB PHARMA S.A.
- 当前专利权人： UCB PHARMA S.A.
- 当前专利权人地址： BE Brussels
- 优先权： GB0514779.8 20050719
- 国际申请： PCT/GB2006/002649 WO 20060717
- 主分类号： C07K16/18
- IPC分类号： C07K16/18 ; C07K1/00
摘要：
The present invention relates to a new class of modified antibody fragments. The present invention provides an antibody fragment to which one or more effector molecules is attached characterized in that the native interchain disulphide bond between the heavy (CHI) and light (CL) chain constant regions is absent and the heavy chain (CHI) and light chain (CL) constant regions are linked by an interchain disulphide bond between a pair of engineered cysteines, one in the light chain constant (CL) region and the other in the heavy chain constant (CHI) region.
公开/授权文献
- US08053562B2 Modified antibody fragments 公开/授权日：2011-11-08
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