发明申请
US20080274109A1 Myeloid Progenitor Inhibitory Factor-1 (MPIF-1), Monocyte Colony Inhibitory Factor (M-CIF), and Macrophage Inhibitory Factor-4 (MIP-4)
失效
髓系祖细胞抑制因子-1（MPIF-1），单核细胞集落抑制因子（M-CIF）和巨噬细胞抑制因子-4（MIP-4）
- 专利标题： Myeloid Progenitor Inhibitory Factor-1 (MPIF-1), Monocyte Colony Inhibitory Factor (M-CIF), and Macrophage Inhibitory Factor-4 (MIP-4)
- 专利标题（中）： 髓系祖细胞抑制因子-1（MPIF-1），单核细胞集落抑制因子（M-CIF）和巨噬细胞抑制因子-4（MIP-4）
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申请号： US12111079申请日： 2008-04-28
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公开(公告)号： US20080274109A1公开(公告)日： 2008-11-06
- 发明人: Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
- 申请人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
- 申请人地址： US MD Rockville
- 专利权人： Human Genome Sciences, Inc.
- 当前专利权人： Human Genome Sciences, Inc.
- 当前专利权人地址： US MD Rockville
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07H21/04 ; C12Q1/68 ; C07K14/00 ; G01N33/53 ; A61P43/00 ; A61K38/00 ; C12Q1/00 ; C07K16/18
摘要：
There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
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