Computed tomography (CT) systems are provided that utilize x-ray tube spectra in connection with the generation and/or interpretation of CT data. The disclosed systems and methods use x-ray tube spectra associated with CT systems to enhance contrast and/or image quality, e.g., by making use of energy selective detection techniques. The x-ray spectra may be determined in a variety of ways, e.g., incorporation of a spectral x-ray tube model into the CT system, using the output of Monte-Carlo simulations, and/or processing measured experimental spectral tube data for the CT system. The x-ray tube spectra is generally generated by and/or stored in a computer system associated with the CT system and may be used in support of an energy selective detective method and/or generation of spectral CT images.