An example disclosed method to handle a reference voltage change in a digital power supply includes receiving a first value associated with a first reference voltage having a first voltage magnitude at a digital signal processor of a digital power supply, comparing the first reference voltage to an output voltage of the digital power supply, controlling the digital power supply based on the comparison between the first reference voltage and the output voltage, receiving a second value associated with a second reference voltage having a second voltage magnitude, determining that the first voltage magnitude is different than the second voltage magnitude, in response to determining that the second voltage magnitude is different than the first voltage magnitude, determining a voltage profile, and controlling the digital power supply based on the voltage profile.