发明申请
- 专利标题： Caspase-3 Substrate Comprising Imaging Agents
- 专利标题（中）： 包含成像剂的胱天蛋白酶-3底物
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申请号： US11815360申请日： 2006-02-03
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公开(公告)号： US20080286201A1公开(公告)日： 2008-11-20
- 发明人: Benedicte Guilbert , Sue Champion , Alexander Mark Gibson , Sally-Anne Ricketts , Michelle Avory , Bente E. Arbo
- 申请人： Benedicte Guilbert , Sue Champion , Alexander Mark Gibson , Sally-Anne Ricketts , Michelle Avory , Bente E. Arbo
- 优先权： GB0502277.7 20050204
- 国际申请： PCT/GB2006/000398 WO 20060203
- 主分类号： A61K51/08
- IPC分类号： A61K51/08 ; C12N9/50
摘要：
The present invention relates to diagnostic imaging agents for in vivo imaging. The imaging agents comprise a synthetic caspase-3 substrate peptide labelled with an imaging moiety suitable for diagnostic imaging in vivo. The invention also provides radiopharmaceutical compositions comprising the imaging agents, together with kits for the preparation of the radiopharmaceuticals. Also described are non-radioactive precursors suitable for the preparation of the imaging agents. The imaging agents are useful for the diagnostic imaging and or therapy monitoring in vivo of various disease states where caspase-3 is involved.
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