发明申请
US20080286325A1 CYCLODEXTRIN ELUTION MEDIA FOR MEDICAL DEVICE COATINGS COMPRISING A TAXANE THERAPEUTIC AGENT
审中-公开
用于包含TAXANE治疗剂的医疗装置涂层的环糊精溶液
- 专利标题： CYCLODEXTRIN ELUTION MEDIA FOR MEDICAL DEVICE COATINGS COMPRISING A TAXANE THERAPEUTIC AGENT
- 专利标题（中）： 用于包含TAXANE治疗剂的医疗装置涂层的环糊精溶液
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申请号： US11774322申请日： 2007-07-06
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公开(公告)号： US20080286325A1公开(公告)日： 2008-11-20
- 发明人: Priscilla Reyes , Patrick H. Ruane , Melinda S. Morrell
- 申请人： Priscilla Reyes , Patrick H. Ruane , Melinda S. Morrell
- 申请人地址： US IN West Lafayette
- 专利权人： MED Institute, Inc.
- 当前专利权人： MED Institute, Inc.
- 当前专利权人地址： US IN West Lafayette
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K31/337 ; G01N33/15
摘要：
The present disclosure provides methods of measuring the release of a taxane therapeutic agent from a medical device as a function time in contact with a suitable elution medium. The method preferably comprises the step of contacting a coated medical device comprising a taxane therapeutic agent with an elution medium comprising a cyclodextrin to provide an elution profile indicative of the composition or configuration of a medical device coating comprising a taxane therapeutic agent. The elution profile can provide information about the medical device coating that is useful in lot release testing.