发明申请
US20080287449A1 AZA-TRIPEPTIDE HEPATITIS C SERINE PROTEASE INHIBITORS
审中-公开
AZA-TRIPEPTIDE HEPATITIS C丝氨酸蛋白酶抑制剂
- 专利标题： AZA-TRIPEPTIDE HEPATITIS C SERINE PROTEASE INHIBITORS
- 专利标题（中）： AZA-TRIPEPTIDE HEPATITIS C丝氨酸蛋白酶抑制剂
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申请号： US12108647申请日： 2008-04-24
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公开(公告)号： US20080287449A1公开(公告)日： 2008-11-20
- 发明人: Deqiang Niu , Yat Sun Or , Zhe Wang
- 申请人： Deqiang Niu , Yat Sun Or , Zhe Wang
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61P31/12 ; C07D409/14 ; C07D207/16 ; C07D403/12 ; C07D417/14 ; C07D401/12 ; C07D495/04 ; C07D471/04 ; A61K31/498 ; A61K31/519 ; A61K31/444 ; A61K31/4709 ; A61K31/4035
摘要：
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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